Medical Imaging Cardiac CT Imaging Medical Image ProcessingComputer Assisted SurgeryRadiation Therapy
Osteoporosis ResearchDose Assessment/Dose Reduction

Contact: Prof. Dr. Willi A. Kalender, Ph.D.

The development and the application of imaging modalities for medical diagnosis, therapy planning and support represent a major focus of the IMP's research activities. In particular, projects related to x-ray computed tomography (CT) are recognized worldwide and allowed the IMP to reach a leading position internationally. The basis for this are decades of experience in this field of the institute's director who, in addition to numerous original contributions to CT, developed spiral CT in 1989 and led it to its international breakthrough.

The Institute has its own modern whole-body CT scanner, the dual-source SOMATOM Definition, which is operated in direct cooperation with the manufacturer, Siemens AG Medical Solutions; it allows modifications and evaluation in clinical practice. The most recent activities focus on the introduction of area detectors for faster volume scanning, new approaches to dose reduction including efforts to establish an automatic exposure control and new clinical applications.

We presently focus on spiral CT imaging of the heart which was developed at the IMP in the 1990s, on image-based navigated interventions and therapy and on micro-CT. Dedicated scanners such as a CT-capable C-arm system and several micro-CT scanners of our own development are available for this.

Magnetic resonance tomography (a 1.5 T research scanner is available) , ultrasound in osteoporosis research, positron emission tomography and optical imaging complete the spectrum of activities.

Further contacts:

Selected Publications

  • Kyriakou Y, Kachelrieß M, Knaup M, Krause JU, Kalender WA (2006) Impact of the z -flying focal spot on resolution and artefact behavior for a 64-slice spiral CT scanner. European Radiology 2006; 16: 1206-1215
  • Kachelrieß M, Sourbelle K, Kalender WA (2006) Empirical cupping correction: A first-order raw data precorrection for cone-beam computed tomography. Med. Phys. 2006; 33(5): 1269-1274
  • Kalender WA (2006) X-ray Computed Tomography. Phys Med Biol 2006; 51: R29-R43
  • Kachelrieß M, Knaup M, Kalender WA (2006) Multithreaded cardiac CT. Med. Phys. 2006; 33(7): 2435-2447
  • Kyriakou Y, Riedel T, Kalender WA (2006) Combining deterministic and Monte Carlo calculations for fast estimation of scatter intensities in CT. Phys. Med. Biol. 2006; 51: 4567-4586
  • Kalender WA, Kyriakou Y et al. 64 from 32: Understanding the Magic or the effects of z-Flying Focal Spot (zFFS) Technology 2005 (incl. video: windmill artifacts with and without zFFS) pps
  • Kalender, W.A., Computed Tomography. Fundamentals, System Technology, Image Quality, Applications. 2nd edition, Publicis Corporate Publishing, Erlangen 2005
  • M. Kachelrieß, W. A. Kalender. Presampling, algorithm factors, and noise: Considerations for CT in particular and for medical in general. Med. Phys. 2005; 32(5): 1321-1334
  • Riess T, Fuchs T, Kalender WA. A new method to identify and to correct circular artifacts in X-ray CT images. Physica Medica 2004; XX(2): 43-55
  • Smekal v. L, Kachelrieß M, Stepina E, Kalender WA. Geometric misalignment and calibration in cone-beam tomography. Med Phys 2004; 31(12): 3242-3266
  • Kachelrieß M, Knaup M, Kalender WA. Extended parallel backprojection for standard three-dimensional and phase-correlated four-dimensional axial and spiral cone-beam CT with arbitrary pitch, arbitrary cone-angle, and 100% dose usage. Med. Phys. 2004; 31(6): 1623-1641
  • Schmidt B, Kalender WA. A fast voxel-based Monte Carlo method for scanner- and patient specific dose calculations in computed tomography. Physica Medica 2002; XVIII (2) April-June: 43-53
  • Kachelrieß M, Sennst D-A, Maxlmoser W, Kalender WA. Kymogram detection and kymogram-correlated image reconstruction from subsecond spiral computed tomography scans of the heart. Med. Phys. 29(7): 1489-1503, July 2002.
  • Karolczak M, Schaller S, Engelke K, Lutz A, Traubenreuther U, Wiesent K, Kalender WA. Implementation of a cone-beam reconstruction algorithm for the single-circle source orbit with embedded misalignment correction using homogeneous coordinates. Med. Phys. 2001; 28(10): 2050-2069
  • Engelke K, Süß C, Kalender WA. Stereolithographic models simulating trabecular bone and their characterization by thin-slice- and micro-CT. Eur. Radiol. 2001; 11: 2026-2040
  • Fellner C, Müller W, Georgi J, Taubenreuther U, Fellner FA, Kalender WA. A high-resolution phantom for MRI. Magnetic Resonance Imaging 2001; 19: 899-904
  • Fuchs TOJ, Krause JU, Kalender WA. Measurement of 3D spatial resolution in multi-slice spiral computed tomography. Physica Medica 2001; XVII (3): 129-134
  • Achenbach S, Giesler T, Ropers D, Ulzheimer S, Derlien H, Schulte C, Wenkel E. Moshage W, Bautz W, Daniel W, Kalender WA, Baum U. Detection of coronary artery stenoses by contrast-enhanced, retrospectively electrocardiographically-gated, multislice spiral computed tomography. Circulation 2001; 103: 2535-2538
  • Kachelrieß M, Fuchs T, Schaller S, Kalender W A. Advanced single-slice rebinning for tilted spiral cone-beam CT. Med. Phys., 28(6): 1033-1041, June 2001.
  • Kachelrieß M, Watzke O, Kalender WA. Generalized multi-dimensional adaptive filtering (MAF) for conventional and spiral single-slice, multi-slice and cone-beam CT. Med. Phys., 28(4): 475-490, April 2001.
  • Kachelrieß M, Fuchs T, Lapp R, Sennst D-A, Schaller S, Kalender WA. Image to volume weighting generalized ASSR for arbitrary pitch 3D and phase-correlated 4D spiral cone-beam CT reconstruction. Proc. of the 2001 Int. Meeting on Fully 3D Image Reconstruction, 179-182, November 2001.
  • Schaller S, Flohr T, Klingenbeck K, Krause J, Fuchs T, Kalender WA. Spiral interpolation algorithm for multi-slice spiral CT.
    Part I: Theory. IEEE Transactions on Medical Imaging 2000; 19 (9): 822-834
  • Fuchs T, Krause J, Schaller S, Flohr T, Kalender, WA. Spiral interpolation algorithm for multi-slice spiral CT. Part II: Measurement and evaluation of slice sensitivity profiles and noise at a clinical multislice system. IEEE Transactions on Medical Imaging 2000; 19 (9): 835-847
  • Kachelrieß M, Ulzheimer S,. Kalender WA. ECG-correlated imaging of the heart with subsecond multislice CT. IEEE Transactions on Medical Imaging, 19(9): 888-901, September 2000.
  • Kachelrieß M, Ulzheimer S, Kalender WA. ECG-correlated image reconstruction from subsecond multi-slice spiral CT scans of the heart. Med. Phys., 27(8): 1881-1902, August 2000.
  • Kachelrieß M, Schaller S, Kalender WA.. Advanced single-slice rebinning in cone-beam spiral CT: Theoretical considerations and medical applications. SPIE Medical Imaging Conference Proc., 3979: 494-505, February 2000.
  • Kachelrieß M, Schaller S, Kalender WA.. Advanced single-slice rebinning in cone-beam spiral CT. Med. Phys., 27(4): 754-772, April 2000.